HORDB

General Information

ID: hor006231
Uniprot ID: P56942
Protein name: Neuropeptide-glycine-glutamic acid
Gene name: Pmch
Organism: Mus musculus (Mouse)
Family: MCH family
Source: animal
Expression: Expression is enhanced between postnatal days 10 and 15.|Predominantly expressed in hypothalamus. Also found in heart, intestine, spleen and testis (spermatogonia, early spermatocytes and Sertoli cells). In brain only mature MCH and NEI peptides are prese
Disease: NA
Comments: NA
Taxonomy: Mus (subgenus), Mus (genus), Murinae (subfamily), Muridae (family), Muroidea, Myomorpha (suborder), Rodentia (order), Glires, Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005102 signaling receptor binding; GO:0005179 hormone activity; GO:0030354 melanin-concentrating hormone activity; GO:0031777 type 1 melanin-concentrating hormone receptor binding
GO BP: GO:0002027 regulation of heart rate; GO:0007204 positive regulation of cytosolic calcium ion concentration; GO:0007218 neuropeptide signaling pathway; GO:0007268 chemical synaptic transmission; GO:0007631 feeding behavior; GO:0032227 negative regulation of synaptic transmission, dopaminergic; GO:0042756 drinking behavior; GO:0045776 negative regulation of blood pressure; GO:0046005 positive regulation of circadian sleep/wake cycle, REM sleep; GO:0048168 regulation of neuronal synaptic plasticity
GO CC: GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0005634 nucleus; GO:0045202 synapse

Sequence Information

Sequence: GSVAFPAENGVQNAESTQE
Length: 19
Propeptide: MAKMTLSSYMLMLAFSLFSQGILLSASKSIRNLEDDIVFNTFRMGKAFQKEDTAERSVVAPSLEQYKNDESGFMNDDDNKNSKNTGSKQNLVTHGLPLSLAVKPYLALKGSVAFPAENGVQNAESTQEKREIGDEENSAKFPIGRRDFDMLRCMLGRVYRPCWQV
Signal peptide: MAKMTLSSYMLMLAFSLFSQG
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Activity

Function: MCH may act as a neurotransmitter or neuromodulator in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal.
Mechanism: NA
Cross BBB: NA
Target: Mchr1
Target Unid: Q8JZL2
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure

Disulfide bond: NA
Structure ID: AF-P56942-F1(AlphaFold_DB_ID)

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor006231_AF2.pdb

hor006231_ESM.pdb

Physical Information

Mass:	225623	Formula:	C80H123N23O33
Absent amino acids:	CDHIKLMRWY	Common amino acids:	AE
pI:	3.47	Basic residues:	0
Polar residues:	7	Hydrophobic residues:	6
Hydrophobicity:	-66.32	Boman Index:	-3579
Half-Life:	30 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	46.32
Instability Index:	3814.21	Extinction Coefficient cystines:	0
Absorbance 280nm:	0

Literature

PubMed ID: 16141072
Title: The transcriptional landscape of the mammalian genome.
PubMed ID: 19468303
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
PubMed ID: 8724342
Title: Developmental and stage-dependent expression of melanin-concentrating hormone in mammalian germ cells.
PubMed ID: 8637571
Title: A role for melanin-concentrating hormone in the central regulation of feeding behaviour.
PubMed ID: 10037747
Title: Cellular localization and role of prohormone convertases in the processing of pro-melanin concentrating hormone in mammals.